rainee Name: Supervisor(s): Detecting changes in human brain glutamate using 7-Tesla functional magnetic resonance spectroscopy at short versus long echo times
نویسندگان
چکیده
Introduction: Typically, magnetic resonance spectroscopy sequences attempting to measure glutamate aim to utilize the shortest echo time achievable to reduce the effects of J-coupling and T2 relaxation. However, in 2017, Wong et al. described the optimal echo time for glutamate detection for 7T semi-LASER proton magnetic resonance spectroscopy (1H-MRS) to be in the range of 100 to 125ms, which is almost twice longer than the typical shortest echo achievable with this sequence (Wong et al., ISMRM abstract, 2017). This work aimed to investigate whether one should choose the shortest echo time or the "optimal" echo time when attempting to detect small glutamate concentration changes in a functional MRS paradigm.
منابع مشابه
Anomalous transverse relaxation in 1H spectroscopy in human brain at 4 Tesla.
Longitudinal (T1) and apparent transverse relaxation times (T2) of choline-containing compounds (Cho), creatine/phosphocreatine (Cr/PCr), and N-acetyl aspartate (NAA) were measured in vivo in human brain at 4 Tesla. Measurements were performed using a water suppressed stimulated echo pulse sequence with complete outside volume presaturation to improve volume localization at short echo times. T1...
متن کاملLocalized in vivo human 1H MRS at very short echo times.
A new point-resolved spectroscopy (PRESS) sequence was developed that allows localized human proton MR spectra to be acquired at echo times (TEs) of 10 ms or less. The method was implemented on a 4 Tesla Varian research console and a clinical 3 Tesla Siemens Trio scanner. Human brain spectra acquired in vivo from the prefrontal cortex at TE=8 ms showed improved signals from coupled resonances (...
متن کاملUsing functional magnetic resonance imaging (fMRI) to explore brain function: cortical representations of language critical areas
Pre-operative determination of the dominant hemisphere for speech and speech associated sensory and motor regions has been of great interest for the neurological surgeons. This dilemma has been of at most importance, but difficult to achieve, requiring either invasive (Wada test) or non-invasive methods (Brain Mapping). In the present study we have employed functional Magnetic Resonance Imaging...
متن کاملNet increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla.
After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMRGlc ) in excess of those in oxygen (CMRO2 ) during physiological stimulation, several studies have examined the fate of the extra carbon taken up by the brain, reporting a wide range of changes in brain lactate from 20% to 250%. The present study reports functional magnetic resonance spectroscopy measurem...
متن کاملUsing functional magnetic resonance imaging (fMRI) to explore brain function: cortical representations of language critical areas
Pre-operative determination of the dominant hemisphere for speech and speech associated sensory and motor regions has been of great interest for the neurological surgeons. This dilemma has been of at most importance, but difficult to achieve, requiring either invasive (Wada test) or non-invasive methods (Brain Mapping). In the present study we have employed functional Magnetic Resonance Imaging...
متن کامل